Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 7/20 | 0.59 |
| ▸ | BCR | P11274 | 7/20 | 0.59 |
| ▸ | SRC | P12931 | 3/20 | 0.59 |
| ▸ | EGFR | P00533 | 1/20 | 0.59 |
| ▸ | PRKACA | P17612 | 1/20 | 0.59 |
| ▸ | PRKACG | P22612 | 1/20 | 0.59 |
| ▸ | PRKACB | P22694 | 1/20 | 0.59 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.55 |
| ▸ | PLK1 | P53350 | 2/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4909103 | 0.88 | PLK1 (0.50) | ABL1BCRSRCEGFRPRKACA | |
| SCHEMBL14172505 | 0.87 | CYP19A1 (0.47) | ABL1BCRSRCEGFRPRKACA | |
| SCHEMBL4733854 | 0.86 | PLK1 (0.58) | ABL1BCRSRCEGFRPLK1 | |
| SCHEMBL4908502 | 0.86 | SMG1 (0.52) | ABL1BCRCYP19A1MAPK10CDK4 | |
| SCHEMBL4909096 | 0.86 | PIK3CG (0.59) | ABL1BCRSRCEGFRCAMK2D | |
| SCHEMBL4733315 | 0.84 | ABL1 (0.50) | ABL1BCRCDK5CYP19A1JAK2 | |
| SCHEMBL4906193 | 0.84 | ABL1 (0.63) | ABL1BCRSRCEGFRPLK1 | |
| SCHEMBL4738283 | 0.83 | MEN1 (0.59) | PLK1CDK5CYP19A1MEN1NPC1 | |
| SCHEMBL4735369 | 0.83 | MAPK10 (0.49) | ABL1BCRCAMK2DPLK1CDK5 | |
| SCHEMBL4803114 | 0.81 | PLK1 (0.64) | ABL1BCRSRCEGFRPLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005012262-A1 | 2-AMINOPHENYL-4-PHENYLPYRIMIDINES AS KINASE INHIBITORS | CYCLACEL LIMITED (GB) | 2005-02-10 | — | — | WO | disclosed |