Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 4/20 | 0.68 |
| ▸ | BCR | P11274 | 3/20 | 0.68 |
| ▸ | PRKCA | P17252 | 3/20 | 0.68 |
| ▸ | EGFR | P00533 | 1/20 | 0.67 |
| ▸ | SRC | P12931 | 1/20 | 0.67 |
| ▸ | CDK2 | P24941 | 8/20 | 0.66 |
| ▸ | CDK4 | P11802 | 8/20 | 0.66 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.64 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.64 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.64 |
| ▸ | PLK1 | P53350 | 1/20 | 0.63 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.59 |
| ▸ | CDK9 | P50750 | 3/20 | 0.59 |
| ▸ | GSK3B | P49841 | 3/20 | 0.59 |
| ▸ | CDK1 | P06493 | 2/20 | 0.59 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.59 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.59 |
| ▸ | CDK7 | P50613 | 2/20 | 0.59 |
| ▸ | CCNH | P51946 | 2/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4738534 | 0.90 | PIK3CA (0.78) | ABL1BCRPRKCAEGFRSRC | |
| SCHEMBL824007 | 0.85 | ABL1 (0.84) | ABL1BCRPRKCAEGFRSRC | |
| SCHEMBL4733637 | 0.85 | ABL1 (0.76) | ABL1BCRPRKCAEGFRSRC | |
| SCHEMBL4734534 | 0.81 | ABL1 (0.68) | ABL1BCRPRKCAEGFRSRC | |
| SCHEMBL1144 | 0.81 | ABL1 (1.00) | ABL1BCRPRKCAEGFRSRC | |
| SCHEMBL4737544 | 0.81 | CDK2 (0.65) | ABL1BCRPRKCAEGFRSRC | |
| SCHEMBL4733655 | 0.81 | PIK3CG (0.76) | ABL1BCRPRKCAEGFRSRC | |
| SCHEMBL4739200 | 0.81 | ABL1 (0.76) | ABL1BCRPRKCAEGFRSRC | |
| SCHEMBL4734622 | 0.81 | ABL1 (0.76) | ABL1BCRPRKCAEGFRSRC | |
| SCHEMBL1977 | 0.80 | ABL1 (1.00) | ABL1BCRPRKCAEGFRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005012262-A1 | 2-AMINOPHENYL-4-PHENYLPYRIMIDINES AS KINASE INHIBITORS | CYCLACEL LIMITED (GB) | 2005-02-10 | — | — | WO | disclosed |