Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | LONP1 | P36776 | 6/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | PSMB5 | P28074 | 4/20 | 0.52 |
| ▸ | PSMB11 | A5LHX3 | 3/20 | 0.52 |
| ▸ | PSMA7 | O14818 | 3/20 | 0.52 |
| ▸ | PSMB1 | P20618 | 3/20 | 0.52 |
| ▸ | PSMA1 | P25786 | 3/20 | 0.52 |
| ▸ | PSMA2 | P25787 | 3/20 | 0.52 |
| ▸ | PSMA3 | P25788 | 3/20 | 0.52 |
| ▸ | PSMA4 | P25789 | 3/20 | 0.52 |
| ▸ | PSMB8 | P28062 | 3/20 | 0.52 |
| ▸ | PSMB9 | P28065 | 3/20 | 0.52 |
| ▸ | PSMA5 | P28066 | 3/20 | 0.52 |
| ▸ | PSMB4 | P28070 | 3/20 | 0.52 |
| ▸ | PSMB6 | P28072 | 3/20 | 0.52 |
| ▸ | PSMB10 | P40306 | 3/20 | 0.52 |
| ▸ | PSMB3 | P49720 | 3/20 | 0.52 |
| ▸ | PSMB2 | P49721 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16350201 | 0.89 | KDM4E (0.56) | KDM4ELONP1SMN1; SMN2HTTPSMB5 | |
| SCHEMBL29420556 | 0.84 | SMN1; SMN2 (0.56) | KDM4ELONP1SMN1; SMN2HTTPSMB5 | |
| SCHEMBL9911459 | 0.84 | SMN1; SMN2 (0.56) | KDM4ELONP1SMN1; SMN2HTTPSMB5 | |
| Hydrochloric Acid SCHEMBL27788898 | 0.83 | SMN1; SMN2 (0.55) | KDM4ELONP1SMN1; SMN2HTTPSMB5 | |
| SCHEMBL30170152 | 0.83 | LONP1 (0.59) | KDM4ELONP1SMN1; SMN2HTTPSMB5 | |
| SCHEMBL13085309 | 0.81 | KDM4E (0.52) | KDM4ELONP1SMN1; SMN2HTTPSMB5 | |
| SCHEMBL5837260 | 0.81 | LONP1 (0.60) | KDM4ELONP1SMN1; SMN2HTTPSMB5 | |
| SCHEMBL21968901 | 0.81 | LONP1 (0.60) | KDM4ELONP1SMN1; SMN2HTTPSMB5 | |
| SCHEMBL30511086 | 0.81 | SMN1; SMN2 (0.53) | KDM4ELONP1SMN1; SMN2HTTPSMB5 | |
| SCHEMBL9607089 | 0.80 | LONP1 (0.58) | KDM4ELONP1SMN1; SMN2HTTPSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449447-B2 | Peptidomimetic NS3-serine protease inhibitors of hepatitis C virus | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| WO-2005021584-A2 | NOVEL PEPTIDOMIMETIC NS3-SERINE PROTEASE INHIBITORS OF HEPATITIS C VIRUS | SCHERING CORPORATION (US) | 2005-03-10 | — | — | WO | disclosed |