Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 1.00 |
| ▸ | CTSD | P07339 | 2/20 | 0.76 |
| ▸ | CTSE | P14091 | 2/20 | 0.76 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13497500 | 1.00 | BACE1 (1.00) | BACE1CTSDCTSEBACE2 | |
| SCHEMBL12854878 | 1.00 | BACE1 (1.00) | BACE1CTSDCTSEBACE2 | |
| SCHEMBL8294383 | 0.90 | BACE1 (0.82) | BACE1 | |
| SCHEMBL13497585 | 0.89 | BACE1 (1.00) | BACE1CTSDCTSEBACE2 | |
| SCHEMBL13341065 | 0.89 | BACE1 (1.00) | BACE1CTSDCTSEBACE2 | |
| SCHEMBL12854864 | 0.89 | BACE1 (1.00) | BACE1CTSDCTSEBACE2 | |
| SCHEMBL12854872 | 0.88 | BACE1 (0.81) | BACE1CTSDCTSEBACE2 | |
| SCHEMBL13497537 | 0.88 | BACE1 (0.81) | BACE1CTSDCTSEBACE2 | |
| SCHEMBL13497441 | 0.88 | BACE1 (1.00) | BACE1 | |
| SCHEMBL8292705 | 0.88 | BACE1 (1.00) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016876-A2 | CYCLIC AMINE BACE-1 INHIBITORS HAVING A BENZAMIDE SUBSTITUENT | SCHERING CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |