Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 3/20 | 0.81 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.81 |
| ▸ | KCNA5 | P22460 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL498597 | 0.90 | KCNK3 (1.00) | KCNK3KCNK9KCNA5BRAF | |
| SCHEMBL29761432 | 0.90 | KCNK3 (1.00) | KCNK3KCNK9KCNA5BRAF | |
| SCHEMBL13801055 | 0.90 | KCNK3 (1.00) | KCNK3KCNK9KCNA5BRAF | |
| SCHEMBL498598 | 0.90 | KCNK3 (1.00) | KCNK3KCNK9KCNA5BRAF | |
| SCHEMBL13480244 | 0.81 | KCNK3 (0.82) | KCNK3KCNK9KCNA5ALDH1A1HPGD | |
| SCHEMBL12200906 | 0.76 | KCNK3 (0.60) | KCNK3KCNK9KCNA5ALDH1A1HPGD | |
| SCHEMBL2717908 | 0.74 | HSD17B10 (0.58) | KCNK3KCNK9KCNA5ALDH1A1HPGD | |
| SCHEMBL12201305 | 0.73 | KCNA5 (0.87) | KCNK3KCNK9KCNA5ALDH1A1HPGD | |
| SCHEMBL12201303 | 0.72 | KCNA5 (0.54) | KCNK3KCNK9KCNA5ALDH1A1HPGD | |
| SCHEMBL25219425 | 0.72 | CYP1A2 (0.56) | KCNK3KCNK9KCNA5ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005025674-A1 | COMBINATION OF PHENYLCARBOXAMIDES WITH BETA-ADRENERGIC RECEPTOR BLOCKERS AND USE THEREOF FOR THE TREATMENT OF ATRIAL ARRHYTHMIAS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2005-03-24 | — | — | WO | disclosed |