Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 6/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.56 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.51 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.51 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.51 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.51 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6290986 | 0.82 | SPHK1 (0.59) | SPHK1CHEK1SPHK2MAPTSMN1; SMN2 | |
| SCHEMBL23454623 | 0.82 | SPHK1 (0.59) | SPHK1CHEK1SPHK2MAPTSMN1; SMN2 | |
| SCHEMBL5264997 | 0.82 | MEN1 (0.61) | SPHK1CHEK1SPHK2MAPTSMN1; SMN2 | |
| SCHEMBL9267426 | 0.82 | MEN1 (0.61) | SPHK1CHEK1SPHK2MAPTSMN1; SMN2 | |
| SCHEMBL26266218 | 0.81 | SPHK1 (0.68) | SPHK1CHEK1SPHK2S1PR1S1PR3 | |
| SCHEMBL13107654 | 0.80 | TAAR1 (0.61) | SPHK1CHEK1SPHK2MAPTSMN1; SMN2 | |
| SCHEMBL10792997 | 0.79 | AAK1 (0.62) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| Hydrochloric Acid SCHEMBL11701716 | 0.78 | AAK1 (0.60) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL7825415 | 0.77 | MAPT (0.43) | SPHK1CHEK1SPHK2MAPTSMN1; SMN2 | |
| SCHEMBL11669294 | 0.77 | SPHK1 (0.66) | SPHK1SPHK2MAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178783-A1 | HDAC INHIBITORS | LIXTE BIOTECHNOLOGY, INC. | 2012-07-12 | — | — | US | disclosed |
| US-8143445-B2 | HDAC inhibitors | LIXTE BIOTECHNOLOGY, INC. (US) | 2012-03-27 | — | — | US | disclosed |
| WO-2009045440-A1 | HDAC INHIBITORS | LIXTE BIOTECHNOLOGY HOLDINGS, INC. (US) | 2009-04-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178783-A1 | HDAC INHIBITORS | HDAC3, HDAC4, HDAC7 | SPHK1 939/4885CHEK1 1460/4885SPHK2 901/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.