Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 16/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4705207 | 0.86 | PDE5A (0.73) | PDE5AKCNH2 | |
| SCHEMBL4699845 | 0.85 | PDE5A (0.65) | PDE5AKCNH2 | |
| SCHEMBL4702163 | 0.79 | PDE5A (0.71) | PDE5AKCNH2 | |
| SCHEMBL4701108 | 0.77 | PDE5A (0.62) | PDE5AKCNH2 | |
| SCHEMBL4701111 | 0.77 | PDE5A (0.68) | PDE5AKCNH2 | |
| SCHEMBL8293840 | 0.76 | PDE5A (0.55) | PDE5AKCNH2 | |
| SCHEMBL4703201 | 0.75 | PDE5A (0.74) | PDE5AKCNH2 | |
| SCHEMBL4703014 | 0.74 | PDE5A (0.53) | PDE5AKCNH2 | |
| SCHEMBL14507699 | 0.73 | PDE5A (0.69) | PDE5AKCNH2 | |
| SCHEMBL8295329 | 0.73 | PDE5A (0.69) | PDE5AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005049617-A1 | PYRAZOLOPYRIMIDINES | PFIZER LIMITED (GB) | 2005-06-02 | — | — | WO | disclosed |