Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 19/20 | 0.83 |
| ▸ | DPP8 | Q6V1X1 | 17/20 | 0.83 |
| ▸ | DPP7 | Q9UHL4 | 16/20 | 0.83 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14440603 | 1.00 | DPP4 (0.83) | DPP4DPP8DPP7DPP9 | |
| SCHEMBL8293548 | 0.91 | DPP4 (1.00) | DPP4DPP8DPP7DPP9 | |
| SCHEMBL8293545 | 0.89 | DPP4 (1.00) | DPP4DPP8DPP7 | |
| SCHEMBL14440604 | 0.85 | DPP4 (1.00) | DPP4DPP8DPP7DPP9 | |
| SCHEMBL27193110 | 0.84 | DPP4 (1.00) | DPP4DPP8DPP7 | |
| SCHEMBL27206700 | 0.84 | DPP4 (1.00) | DPP4DPP8DPP7 | |
| SCHEMBL27206771 | 0.84 | DPP4 (1.00) | DPP4DPP8DPP7 | |
| SCHEMBL8293546 | 0.84 | DPP4 (1.00) | DPP4DPP8DPP7 | |
| SCHEMBL27193109 | 0.84 | DPP4 (1.00) | DPP4DPP8DPP7 | |
| SCHEMBL8295832 | 0.84 | DPP4 (0.81) | DPP4DPP8DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651623-B1 | HEXAHYDRODIAZEPINONES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO INC (US) | 2008-12-17 | — | — | EP | disclosed |
| WO-2005011581-A2 | HEXAHYDRODIAZEPINONES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO., INC. (US) | 2005-02-10 | — | — | WO | disclosed |