Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2B6 | P20813 | 1/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 4/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | QPCT | Q16769 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10572039 | 0.75 | CYP2B6 (0.39) | CYP2B6TBXAS1KMT2AMEN1GAA | |
| SCHEMBL2066343 | 0.74 | KDM4C (0.41) | KDM4CKMT2AMEN1L3MBTL1 | |
| SCHEMBL7454755 | 0.74 | MEN1 (0.45) | KDM4CKMT2AMEN1L3MBTL1 | |
| SCHEMBL1485249 | 0.74 | KDM4C (0.42) | KDM4CKMT2AMEN1L3MBTL1 | |
| SCHEMBL1485300 | 0.74 | KDM4C (0.42) | KDM4CKMT2AMEN1L3MBTL1 | |
| SCHEMBL15008247 | 0.71 | KDM4C (0.42) | KDM4CKMT2AMEN1L3MBTL1 | |
| SCHEMBL8570928 | 0.71 | CYP2B6 (0.57) | CYP2B6TBXAS1CYP19A1KDM4CKDM4E | |
| SCHEMBL4444887 | 0.71 | MEN1 (0.47) | KDM4CKMT2AMEN1L3MBTL1 | |
| SCHEMBL2066342 | 0.70 | KDM4C (0.38) | KDM4CKMT2AMEN1L3MBTL1 | |
| SCHEMBL5872843 | 0.70 | MEN1 (0.50) | KDM4CKMT2AMEN1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005009965-A1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS | PFIZER LIMITED (GB) | 2005-02-03 | — | — | WO | disclosed |