Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 1/20 | 0.55 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.55 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.55 |
| ▸ | KLK6 | Q92876 | 1/20 | 0.55 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
| ▸ | HTR6 | P50406 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | TSPO | P30536 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1757929 | 0.88 | AKR1C2 (0.54) | PRSS1PRSS2PRSS3KLK6SIRT1 | |
| SCHEMBL8291738 | 0.86 | KDM4E (0.69) | KLK6KDM4ELMNAALDH1A1MEN1 | |
| SCHEMBL6222629 | 0.85 | GAA (0.63) | KDM4ELMNAHTR7HTR6ALDH1A1 | |
| SCHEMBL10277244 | 0.84 | KDM4E (0.51) | KLK6KDM4ELMNAHTR7HTR6 | |
| SCHEMBL5190391 | 0.84 | JAK2 (0.55) | KDM4ELMNAALDH1A1MEN1GAA | |
| SCHEMBL1191675 | 0.84 | KDM4E (0.51) | KLK6KDM4ELMNAALDH1A1MEN1 | |
| SCHEMBL11331437 | 0.83 | KDM4E (0.49) | PRSS1PRSS2PRSS3KLK6KDM4E | |
| SCHEMBL8298998 | 0.83 | KDM4E (0.51) | PRSS1PRSS2PRSS3KLK6SIRT1 | |
| SCHEMBL1757962 | 0.83 | KDM4E (0.73) | PRSS1PRSS2PRSS3KLK6SIRT1 | |
| SCHEMBL7964334 | 0.83 | HCRTR1 (0.69) | KDM4ELMNAALDH1A1MEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0620214-B1 | 1H-indole-3-acetic acid hydrazide sPLA2 inhibitors | LILLY CO ELI (US) | 1999-03-03 | — | — | EP | disclosed |
| US-5578634-A | SEPTIC SHOCK TREATMENT | ELI LILLY AND COMPANY (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0620214-A1 | 1H-indole-3-acetic acid hydrazide sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 1994-10-19 | — | — | EP | disclosed |