Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 7/20 | 1.00 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 1.00 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 1.00 |
| ▸ | HDAC3 | O15379 | 6/20 | 1.00 |
| ▸ | HDAC2 | Q92769 | 3/20 | 1.00 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 1.00 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 1.00 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 1.00 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 1.00 |
| ▸ | HDAC4 | P56524 | 1/20 | 1.00 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 1.00 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.73 |
| ▸ | GBA1 | P04062 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | FAAH | O00519 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1365506 | 0.84 | HDAC3 (1.00) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL17293731 | 0.84 | HDAC3 (0.73) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL27592378 | 0.84 | EPHX2 (1.00) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL12931877 | 0.84 | EPHX2 (1.00) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL15779858 | 0.84 | EPHX2 (0.76) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL5477403 | 0.84 | HDAC3 (0.73) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL5355989 | 0.84 | HDAC3 (0.73) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL1193774 | 0.84 | HDAC3 (0.72) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL12237542 | 0.84 | HDAC3 (0.72) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL20985682 | 0.84 | HDAC3 (0.72) | HDAC1HDAC8HDAC6HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2258677-B1 | HISTONE DEACETYLASE INHIBITORS | UNIV GEORGETOWN (US) | 2014-06-18 | — | — | EP | disclosed |
| US-8748463-B2 | Histone deacetylase inhibitors and methods of use thereof | GEORGETOWN UNIVERSITY (US) | 2014-06-10 | — | — | US | disclosed |
| US-8748463-B2 | Histone deacetylase inhibitors and methods of use thereof | GEORGETOWN UNIVERSITY (US) | 2014-06-10 | — | — | US | disclosed |
| US-20130065963-A1 | Histone Deacetylase Inhibitors and Methods of Use Thereof | GEORGETOWN UNIVERSITY (US) | 2013-03-14 | — | — | US | disclosed |
| US-20130065963-A1 | Histone Deacetylase Inhibitors and Methods of Use Thereof | GEORGETOWN UNIVERSITY (US) | 2013-03-14 | — | — | US | disclosed |
| US-8222451-B2 | Histone deacetylase inhibitors and methods of use thereof | GEORGETOWN UNIVERSITY (US) | 2012-07-17 | — | — | US | disclosed |
| US-8222451-B2 | Histone deacetylase inhibitors and methods of use thereof | GEORGETOWN UNIVERSITY (US) | 2012-07-17 | — | — | US | disclosed |
| US-8067600-B2 | Histone deacetylase inhibitors and methods of use thereof | GEORGETOWN UNIVERSITY (US) | 2011-11-29 | — | — | US | disclosed |
| US-8067600-B2 | Histone deacetylase inhibitors and methods of use thereof | GEORGETOWN UNIVERSITY (US) | 2011-11-29 | — | — | US | disclosed |
| US-20110098504-A1 | Histone Deacetylase Inhibitors and Methods of Use Thereof | GEORGETOWN UNIVERSITY (US) | 2011-04-28 | — | — | US | disclosed |
| US-20110098504-A1 | Histone Deacetylase Inhibitors and Methods of Use Thereof | GEORGETOWN UNIVERSITY (US) | 2011-04-28 | — | — | US | disclosed |
| US-7842835-B2 | Histone deacetylase inhibitors and methods of use thereof | GEORGETOWN UNIVERSITY (US) | 2010-11-30 | — | — | US | disclosed |
| US-7842835-B2 | Histone deacetylase inhibitors and methods of use thereof | GEORGETOWN UNIVERSITY (US) | 2010-11-30 | — | — | US | disclosed |
| US-7507828-B2 | Histone deacetylase inhibitors and methods of use thereof | GEORGETOWN UNIVERSITY (US) | 2009-03-24 | — | — | US | disclosed |
| US-7507828-B2 | Histone deacetylase inhibitors and methods of use thereof | GEORGETOWN UNIVERSITY (US) | 2009-03-24 | — | — | US | disclosed |
| WO-2005007091-A2 | HISTONE DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF | GEORGETOWN UNIVERSITY (US) | 2005-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130065963-A1 | Histone Deacetylase Inhibitors and Methods of Use Thereof | HDAC5, HDAC6, HDAC1 | HDAC1 3/4885HDAC8 9/4885HDAC6 2/4885 |
| US-20110098504-A1 | Histone Deacetylase Inhibitors and Methods of Use Thereof | HDAC5, HDAC6, HDAC1 | HDAC1 3/4885HDAC8 9/4885HDAC6 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.