Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5747650 | 0.88 | PDE4B (0.47) | PDE4BPDE4APDE4D | |
| SCHEMBL5747038 | 0.83 | PDE4B (0.47) | PDE4BPDE4APDE4DCYP3A4 | |
| SCHEMBL5746063 | 0.83 | PDE4B (0.47) | PDE4BPDE4APDE4D | |
| SCHEMBL3208294 | 0.83 | PDE4B (0.58) | PDE4BPDE4APDE4D | |
| SCHEMBL3208300 | 0.83 | PDE4B (0.58) | PDE4BPDE4APDE4D | |
| SCHEMBL3217617 | 0.82 | PDE4B (0.54) | PDE4BPDE4APDE4DCYP3A4 | |
| SCHEMBL3217622 | 0.82 | PDE4B (0.54) | PDE4BPDE4APDE4DCYP3A4 | |
| Hydrochloric Acid SCHEMBL3202660 | 0.81 | PDE4B (0.54) | PDE4BPDE4APDE4DCYP3A4 | |
| Hydrochloric Acid SCHEMBL3202666 | 0.81 | PDE4B (0.54) | PDE4BPDE4APDE4DCYP3A4 | |
| SCHEMBL5746109 | 0.80 | PDE4B (0.48) | PDE4BPDE4APDE4DCYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005009989-A1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS | PFIZER LIMITED (GB) | 2005-02-03 | — | — | WO | disclosed |