Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.35 |
| ▸ | GCK | P35557 | 1/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20564919 | 0.88 | KMT2A (0.53) | KMT2AMEN1ATRKDM4CPOLB | |
| SCHEMBL5868268 | 0.86 | KMT2A (0.42) | KMT2AMEN1ATRKDM4CPOLB | |
| SCHEMBL29001339 | 0.85 | KMT2A (0.51) | KMT2AMEN1ATRPOLBTDP1 | |
| SCHEMBL20213510 | 0.80 | KDM4C (0.42) | KMT2AMEN1ATRKDM4CMET | |
| SCHEMBL20228835 | 0.80 | KDM4C (0.42) | KMT2AMEN1ATRKDM4CMET | |
| SCHEMBL25389070 | 0.80 | KDM4C (0.42) | KMT2AMEN1ATRKDM4CMET | |
| SCHEMBL28353872 | 0.80 | KDM4C (0.42) | KMT2AMEN1ATRKDM4CMET | |
| SCHEMBL26133560 | 0.80 | MEN1 (0.40) | KMT2AMEN1ATRKDM4CMET | |
| SCHEMBL26132503 | 0.77 | KDM4C (0.40) | KMT2AMEN1ATRKDM4CMET | |
| SCHEMBL4196206 | 0.77 | MEN1 (0.46) | KMT2AMEN1KDM4CL3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005009965-A1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS | PFIZER LIMITED (GB) | 2005-02-03 | — | — | WO | disclosed |