Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 6/20 | 0.36 |
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24103862 | 0.93 | MEN1 (0.55) | MEN1KMT2AKDM4CL3MBTL1MET | |
| SCHEMBL20565389 | 0.87 | MEN1 (0.43) | MEN1KMT2AKDM4CL3MBTL1MET | |
| SCHEMBL5823151 | 0.85 | KMT2A (0.42) | MEN1KMT2AKDM4CL3MBTL1MET | |
| SCHEMBL29001335 | 0.83 | KMT2A (0.39) | MEN1KMT2AKDM4CNPC1RAB9A | |
| SCHEMBL30420188 | 0.82 | MEN1 (0.48) | MEN1KMT2AKDM4CL3MBTL1MET | |
| SCHEMBL6167571 | 0.80 | MEN1 (0.49) | MEN1KMT2AKDM4CMETEP300 | |
| SCHEMBL4191329 | 0.79 | MEN1 (0.45) | MEN1KMT2AKDM4CL3MBTL1NPC1 | |
| SCHEMBL4181795 | 0.79 | MEN1 (0.45) | MEN1KMT2AKDM4CL3MBTL1NPC1 | |
| SCHEMBL30268686 | 0.79 | KDM4C (0.46) | MEN1KMT2AKDM4CL3MBTL1MET | |
| SCHEMBL24103840 | 0.79 | KMT2A (0.45) | MEN1KMT2AKDM4CNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005009965-A1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS | PFIZER LIMITED (GB) | 2005-02-03 | — | — | WO | disclosed |