Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 10/20 | 1.00 |
| ▸ | GRIA2 | P42262 | 9/20 | 1.00 |
| ▸ | GRIA4 | P48058 | 9/20 | 1.00 |
| ▸ | GRIK5 | Q16478 | 9/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | GRIA3 | P42263 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | BLM | P54132 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5000789 | 1.00 | GRIA1 (1.00) | GRIA1GRIA2GRIA4GRIK5CYP1A2 | |
| SCHEMBL12648446 | 0.82 | GRIA1 (1.00) | GRIA1GRIA2GRIA4GRIK5CYP1A2 | |
| SCHEMBL8631021 | 0.82 | GRIA1 (0.69) | GRIA1GRIA2GRIA4GRIK5CYP1A2 | |
| SCHEMBL13957600 | 0.82 | GRIA1 (0.69) | GRIA1GRIA2GRIA4GRIK5CYP1A2 | |
| SCHEMBL4311549 | 0.82 | GRIA1 (1.00) | GRIA1GRIA2GRIA4GRIK5CYP1A2 | |
| SCHEMBL401659 | 0.82 | GRIA1 (1.00) | GRIA1GRIA2GRIA4GRIK5CYP1A2 | |
| SCHEMBL14478236 | 0.80 | GRIA1 (0.66) | GRIA1GRIA2GRIA4GRIK5CYP1A2 | |
| SCHEMBL25312715 | 0.79 | GRIA1 (0.66) | GRIA1GRIA2GRIA4GRIK5CYP1A2 | |
| SCHEMBL29499324 | 0.79 | GRIA1 (0.64) | GRIA1GRIA2GRIA4GRIK5CYP1A2 | |
| SCHEMBL12113221 | 0.77 | GRIA1 (0.62) | GRIA1GRIA2GRIA4GRIK5CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005007106-A2 | COMPOSITIONS OF A CYCLOOXYGENASE-2 SELECTIVE INHIBITOR AND A NON-NMDA GLUTAMATE MODULATOR FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DAMAGE | PHARMACIA CORPORATION (US) | 2005-01-27 | — | — | WO | disclosed |