Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25A | P30304 | 1/20 | 0.45 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 3/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3306398 | 0.98 | CDC25A (0.46) | CDC25APABPC1CTDSP1CHRNB2CHRNB4 | |
| SCHEMBL4899622 | 0.84 | CDC25A (0.49) | CDC25APABPC1CTDSP1CHRNB2CHRNB4 | |
| SCHEMBL4898482 | 0.83 | KDM4E (0.43) | CDC25AKDM4EALDH1A1 | |
| SCHEMBL4904773 | 0.81 | CDC25A (0.54) | CDC25APABPC1CTDSP1CHRNB2CHRNB4 | |
| Methoxyacetic Acid SCHEMBL17418718 | 0.80 | CDC25A (0.44) | CDC25APABPC1CTDSP1CHRNB2CHRNB4 | |
| SCHEMBL17418373 | 0.80 | CDC25A (0.41) | CDC25APABPC1CTDSP1CHRNB2CHRNB4 | |
| Bromide SCHEMBL830831 | 0.79 | KDM4E (0.57) | CDC25APABPC1CTDSP1CHRNB2CHRNB4 | |
| SCHEMBL4901862 | 0.79 | HTT (0.33) | CDC25ACTDSP1HTTALDH1A1 | |
| SCHEMBL372426 | 0.79 | KDM4E (0.56) | CDC25ACTDSP1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL20365995 | 0.78 | KDM4E (0.47) | CDC25APABPC1CTDSP1CHRNB2CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2089414-B1 | USE OF IONIC LIQUIDS FOR MEMBRANE PROTEIN EXTRACTION | MERCK PATENT GMBH (DE) | 2013-03-06 | — | — | EP | claimed |
| US-8143381-B2 | Use of ionic liquids for membrane protein extraction | MERCK PATENT GMBH (DE) | 2012-03-27 | — | — | US | claimed |
| US-20100029917-A1 | USE OF IONIC LIQUIDS FOR MEMBRANE PROTEIN EXTRACTION | MERCK PATENT GMBH (DE) | 2010-02-04 | — | — | US | claimed |
| EP-2089414-A1 | USE OF IONIC LIQUIDS FOR MEMBRANE PROTEIN EXTRACTION | Merck Patent GmbH (DE) | 2009-08-19 | — | — | EP | claimed |
| WO-2008058604-A1 | USE OF IONIC LIQUIDS FOR MEMBRANE PROTEIN EXTRACTION | MERCK PATENT GMBH (DE) | 2008-05-22 | — | — | WO | claimed |
| EP-2089414-B1 | USE OF IONIC LIQUIDS FOR MEMBRANE PROTEIN EXTRACTION | MERCK PATENT GMBH (DE) | 2013-03-06 | — | — | EP | disclosed |
| US-8143381-B2 | Use of ionic liquids for membrane protein extraction | MERCK PATENT GMBH (DE) | 2012-03-27 | — | — | US | disclosed |
| US-20100029917-A1 | USE OF IONIC LIQUIDS FOR MEMBRANE PROTEIN EXTRACTION | MERCK PATENT GMBH (DE) | 2010-02-04 | — | — | US | disclosed |
| EP-2089414-A1 | USE OF IONIC LIQUIDS FOR MEMBRANE PROTEIN EXTRACTION | Merck Patent GmbH (DE) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008058604-A1 | USE OF IONIC LIQUIDS FOR MEMBRANE PROTEIN EXTRACTION | MERCK PATENT GMBH (DE) | 2008-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029917-A1 | USE OF IONIC LIQUIDS FOR MEMBRANE PROTEIN EXTRACTION | APMAP, VAMP8, VAMP7 | CDC25A 4145/4885PABPC1 1899/4885CTDSP1 4581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.