Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.37 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.33 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.33 |
| ▸ | PLG | P00747 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24764929 | 0.82 | KMT2A (0.54) | KMT2ACCNT1CDK9HASPINCYP2A6 | |
| SCHEMBL29950990 | 0.79 | KMT2A (0.51) | KMT2ACCNT1CDK9HASPINCYP2A6 | |
| SCHEMBL1713774 | 0.79 | KMT2A (0.51) | KMT2ACCNT1CDK9HASPINCYP2A6 | |
| SCHEMBL1713542 | 0.79 | KMT2A (0.51) | KMT2ACCNT1CDK9HASPINCYP2A6 | |
| SCHEMBL1337617 | 0.79 | KMT2A (0.51) | KMT2ACCNT1CDK9HASPINCYP2A6 | |
| SCHEMBL1563587 | 0.79 | KMT2A (0.51) | KMT2ACCNT1CDK9HASPINCYP2A6 | |
| SCHEMBL29953688 | 0.79 | KMT2A (0.51) | KMT2ACCNT1CDK9HASPINCYP2A6 | |
| SCHEMBL9906847 | 0.79 | KMT2A (0.51) | KMT2ACCNT1CDK9HASPINCYP2A6 | |
| SCHEMBL29953503 | 0.79 | KMT2A (0.51) | KMT2ACCNT1CDK9HASPINCYP2A6 | |
| SCHEMBL21902715 | 0.76 | DYRK1A (0.38) | AXLCDK8TNIKGSK3BMAP3K11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079133-A2 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON, INC. (US) | 2011-06-30 | — | — | WO | disclosed |
| WO-2004101565-A2 | JNK INHIBITORS | EISAI CO., LTD. (JP) | 2004-11-25 | — | — | WO | disclosed |