Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8300368 | 0.80 | MEN1 (0.33) | MEN1KMT2AALDH1A1TSHRGPR119 | |
| SCHEMBL8300314 | 0.80 | MEN1 (0.37) | MEN1KMT2AALDH1A1TSHRGPR119 | |
| SCHEMBL8292248 | 0.75 | NR1H2 (0.35) | MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL27297555 | 0.74 | MEN1 (0.37) | MEN1KMT2AALDH1A1TSHRGPR119 | |
| SCHEMBL10474713 | 0.73 | CHRM2 (0.37) | MEN1KMT2AALDH1A1TSHRGPR119 | |
| SCHEMBL8292249 | 0.73 | MEN1 (0.32) | MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL38660321 | 0.71 | MEN1 (0.43) | MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL116483 | 0.71 | MEN1 (0.43) | MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL8291352 | 0.70 | SMYD3 (0.33) | — | |
| SCHEMBL25204927 | 0.70 | MEN1 (0.44) | MEN1KMT2AALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0658545-B1 | Decahydro-isoquinoline derivatives | LILLY CO ELI (US) | 1999-09-29 | — | — | EP | disclosed |
| EP-0383504-B1 | Decahydro isoquinoline derivatives, process for their preparation and use as medicines | LILLY CO ELI (US) | 1995-07-19 | — | — | EP | disclosed |
| EP-0658545-A1 | Decahydro-isoquinoline derivatives | ELI LILLY AND COMPANY (US) | 1995-06-21 | — | — | EP | disclosed |
| EP-0383504-A2 | Decahydro isoquinoline derivatives, process for their preparation and use as medicines | ELI LILLY AND COMPANY (US) | 1990-08-22 | — | — | EP | disclosed |
| US-4902695-A | ISOQUINOLINE DERIVATIVES; NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY (US) | 1990-02-20 | — | — | US | disclosed |