Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 2/20 | 0.57 |
| ▸ | CALCRL | Q16602 | 15/20 | 0.56 |
| ▸ | RAMP1 | O60894 | 6/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30231301 | 0.82 | CALCRL (0.58) | CHRM4CALCRLRAMP1 | |
| SCHEMBL2103739 | 0.82 | CALCRL (0.58) | CHRM4CALCRLRAMP1 | |
| SCHEMBL8299867 | 0.82 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9ACYP2C19HDAC1 | |
| SCHEMBL2860494 | 0.81 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1RAB9ACYP2C19HDAC1 | |
| SCHEMBL14044286 | 0.81 | CALCRL (0.60) | CALCRLRAMP1 | |
| SCHEMBL2604336 | 0.80 | CALCRL (0.58) | CHRM4CALCRLRAMP1CHRM1 | |
| SCHEMBL14044425 | 0.80 | CALCRL (0.61) | CALCRL | |
| SCHEMBL17870757 | 0.79 | CALCRL (0.63) | CHRM4CALCRLRAMP1 | |
| SCHEMBL14044357 | 0.79 | CALCRL (0.51) | CHRM4CALCRLRAMP1CHRM1 | |
| SCHEMBL14044461 | 0.79 | CALCRL (0.52) | CALCRLRAMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977135-A | Bicyclic heterocycles | ZENECA LTD. (GB) | 1999-11-02 | — | — | US | disclosed |
| EP-0733051-B1 | BICYCLIC HETEROCYCLES AS NEUROKININ A ANTAGONISTS | ZENECA LTD (GB) | 1999-09-15 | — | — | EP | disclosed |
| US-5602138-A | NKA affecting piperidyl heterobicyclic compounds | ZENECA LIMITED (GB) | 1997-02-11 | — | — | US | disclosed |
| EP-0733051-A1 | BICYCLIC HETEROCYCLES AS NEUROKININ A ANTAGONISTS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1995015961-A1 | BICYCLIC HETEROCYCLES AS NEUROKININ A ANTAGONISTS | ZENECA LIMITED (GB) | 1995-06-15 | — | — | WO | disclosed |