Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 4/20 | 0.53 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13595122 | 1.00 | PDE4B (0.53) | PDE4BNR1H2USP2SMN1; SMN2EPHX1 | |
| SCHEMBL22160615 | 1.00 | PDE4B (0.53) | PDE4BNR1H2USP2SMN1; SMN2EPHX1 | |
| SCHEMBL8268416 | 1.00 | PDE4B (0.53) | PDE4BNR1H2USP2SMN1; SMN2EPHX1 | |
| SCHEMBL1759697 | 1.00 | PDE4B (0.53) | PDE4BNR1H2USP2SMN1; SMN2EPHX1 | |
| SCHEMBL18725620 | 0.93 | PDE4B (0.58) | PDE4BNR1H2USP2SMN1; SMN2EPHX1 | |
| SCHEMBL22160718 | 0.93 | PDE4B (0.58) | PDE4BNR1H2USP2SMN1; SMN2EPHX1 | |
| SCHEMBL22160720 | 0.93 | PDE4B (0.58) | PDE4BNR1H2USP2SMN1; SMN2EPHX1 | |
| SCHEMBL1051376 | 0.90 | NR1H2 (0.53) | PDE4BNR1H2USP2SMN1; SMN2EPHX1 | |
| SCHEMBL6065186 | 0.90 | NR1H2 (0.53) | PDE4BNR1H2USP2SMN1; SMN2EPHX1 | |
| SCHEMBL1052921 | 0.90 | NR1H2 (0.53) | PDE4BNR1H2USP2SMN1; SMN2EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005037826-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | INCYTE CORPORATION (US) | 2005-04-28 | — | — | WO | disclosed |