Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 17/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.46 |
| ▸ | PDE4A | P27815 | 13/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 13/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5022733 | 0.91 | PDE4B (0.52) | PDE4BPDE4DPDE4APDE4CCYP19A1 | |
| SCHEMBL8298189 | 0.85 | PDE4B (0.62) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL8298275 | 0.84 | CYP19A1 (0.47) | PDE4BPDE4DPDE4APDE4CCYP19A1 | |
| SCHEMBL8298827 | 0.84 | PDE4B (0.64) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL8298185 | 0.84 | PDE4A (0.46) | PDE4BPDE4DPDE4APDE4CCYP19A1 | |
| SCHEMBL8302105 | 0.83 | PDE4B (0.51) | PDE4BPDE4DPDE4APDE4CCYP19A1 | |
| SCHEMBL8299625 | 0.83 | PDE4B (0.53) | PDE4BPDE4DPDE4APDE4CCYP19A1 | |
| SCHEMBL8298197 | 0.80 | CYP19A1 (0.47) | PDE4BPDE4DPDE4APDE4CCYP19A1 | |
| SCHEMBL5025269 | 0.79 | PDE4D (0.43) | PDE4BPDE4DPDE4APDE4CCYP19A1 | |
| SCHEMBL5022607 | 0.77 | CYP19A1 (0.48) | PDE4BPDE4DPDE4APDE4CCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004111044-A1 | TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS:PROCESS FOR THEIR PREPARATION | GLENMARK PHARMACEUTICALS LTD. (US) | 2004-12-23 | — | — | WO | disclosed |