Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL89517 | 1.00 | NR1H2 (0.47) | NR1H2PDE4BHPGDBRD4EPHX1 | |
| SCHEMBL89501 | 1.00 | NR1H2 (0.47) | NR1H2PDE4BHPGDBRD4EPHX1 | |
| SCHEMBL90294 | 1.00 | NR1H2 (0.47) | NR1H2PDE4BHPGDBRD4EPHX1 | |
| SCHEMBL2900961 | 1.00 | NR1H2 (0.47) | NR1H2PDE4BHPGDBRD4EPHX1 | |
| SCHEMBL13461234 | 1.00 | NR1H2 (0.47) | NR1H2PDE4BHPGDBRD4EPHX1 | |
| SCHEMBL55893 | 1.00 | NR1H2 (0.47) | NR1H2PDE4BHPGDBRD4EPHX1 | |
| SCHEMBL7953060 | 1.00 | NR1H2 (0.47) | NR1H2PDE4BHPGDBRD4EPHX1 | |
| SCHEMBL10283547 | 0.94 | NR1H2 (0.51) | NR1H2PDE4BHPGDBRD4EPHX1 | |
| SCHEMBL89018 | 0.94 | NR1H2 (0.51) | NR1H2PDE4BHPGDBRD4EPHX1 | |
| SCHEMBL13461241 | 0.94 | NR1H2 (0.51) | NR1H2PDE4BHPGDBRD4EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0862435-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1999-02-03 | — | — | EP | disclosed |
| EP-0862435-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-09-09 | — | — | EP | disclosed |
| WO-1997018813-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-05-29 | — | — | WO | disclosed |