Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.64 |
| ▸ | MLNR | O43193 | 1/20 | 0.64 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.64 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.64 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.64 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.64 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.64 |
| ▸ | HTR1A | P08908 | 1/20 | 0.64 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.64 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.64 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.64 |
| ▸ | DRD2 | P14416 | 1/20 | 0.64 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.64 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.64 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.64 |
| ▸ | MAOA | P21397 | 1/20 | 0.64 |
| ▸ | CNR1 | P21554 | 1/20 | 0.64 |
| ▸ | DRD1 | P21728 | 1/20 | 0.64 |
| ▸ | DRD4 | P21917 | 1/20 | 0.64 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8299751 | 0.88 | KCNH2 (0.65) | KCNH2MLNRCACNA1FNR1I2ABCB11 | |
| SCHEMBL8299704 | 0.86 | KCNH2 (0.62) | KCNH2MLNRCACNA1FNR1I2ABCB11 | |
| SCHEMBL8296787 | 0.86 | KCNH2 (0.62) | KCNH2MLNRCACNA1FNR1I2ABCB11 | |
| SCHEMBL8299033 | 0.86 | KCNH2 (0.62) | KCNH2MLNRCACNA1FNR1I2ABCB11 | |
| SCHEMBL8640730 | 0.85 | KCNH2 (0.75) | KCNH2MLNRCACNA1FNR1I2ABCB11 | |
| SCHEMBL8295358 | 0.85 | KCNH2 (0.63) | KCNH2MLNRCACNA1FNR1I2ABCB11 | |
| SCHEMBL8301358 | 0.84 | KCNH2 (0.59) | KCNH2MLNRCACNA1FNR1I2ABCB11 | |
| SCHEMBL8295921 | 0.84 | KCNH2 (0.59) | KCNH2MLNRCACNA1FNR1I2ABCB11 | |
| SCHEMBL8295653 | 0.84 | KCNH2 (0.75) | KCNH2MLNRCACNA1FNR1I2ABCB11 | |
| SCHEMBL9120920 | 0.84 | KCNH2 (0.75) | KCNH2MLNRCACNA1FNR1I2ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0592433-B1 | SERTINDOLE PRODRUGS | LUNDBECK & CO AS H (DK) | 1999-01-20 | — | — | EP | disclosed |
| US-5428036-A | Psychological disorders | H. LUNDBECK A/S (DK) | 1995-06-27 | — | — | US | disclosed |