Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 16/20 | 0.88 |
| ▸ | PDE4B | Q07343 | 15/20 | 0.88 |
| ▸ | PDE4C | Q08493 | 15/20 | 0.88 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.88 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5934209 | 0.94 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DKCNH2 | |
| SCHEMBL5111855 | 0.90 | PDE4A (0.83) | PDE4APDE4BPDE4CPDE4DKCNH2 | |
| SCHEMBL5114088 | 0.89 | PDE4A (0.83) | PDE4APDE4BPDE4CPDE4DKCNH2 | |
| SCHEMBL5141241 | 0.88 | PDE4A (0.90) | PDE4APDE4BPDE4CPDE4DKCNH2 | |
| SCHEMBL5119683 | 0.88 | PDE4A (0.86) | PDE4APDE4BPDE4CPDE4DKCNH2 | |
| SCHEMBL8301920 | 0.88 | PDE4A (0.81) | PDE4APDE4BPDE4CPDE4DKCNH2 | |
| SCHEMBL5344071 | 0.86 | KCNH2 (0.80) | PDE4APDE4BPDE4CPDE4DKCNH2 | |
| SCHEMBL8300300 | 0.86 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DKCNH2 | |
| SCHEMBL5343986 | 0.86 | KCNH2 (0.79) | PDE4APDE4BPDE4CPDE4DKCNH2 | |
| SCHEMBL4790605 | 0.85 | PDE4A (0.81) | PDE4APDE4BPDE4CPDE4DKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004105698-A2 | USE OF PHOSPHATASE INHIBITORS AS ADJUNCT THERAPY FOR PSYCHIATRIC DISORDERS | MERCK & CO., INC. (US) | 2004-12-09 | — | — | WO | disclosed |
| WO-2004048374-A1 | 4-OXO-1-(3-SUBSTITUTED PHENYL-1,4-DIHYDRO-1,8-NAPHTHYRIDINE-3-CARBOXAMIDE PHOSPHODIESTERASE-4 INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2004-06-10 | — | — | WO | disclosed |