Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.32 |
| ▸ | WNT3A | P56704 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1056103 | 0.81 | KDM4E (0.60) | KDM4EALDH1A1PLK1L3MBTL1MAPT | |
| SCHEMBL31160025 | 0.81 | KDM4E (0.60) | KDM4EALDH1A1PLK1L3MBTL1MAPT | |
| SCHEMBL6373245 | 0.76 | KDM4E (0.54) | KDM4EALDH1A1PLK1MAPTPOLB | |
| SCHEMBL23193829 | 0.76 | KDM4E (0.66) | KDM4EALDH1A1L3MBTL1MAPTPOLB | |
| SCHEMBL9053612 | 0.73 | KDM4E (0.42) | KDM4EALDH1A1PLK1L3MBTL1MAPT | |
| Hydrochloric Acid SCHEMBL4164962 | 0.72 | MAPT (0.42) | KDM4EALDH1A1PLK1L3MBTL1MAPT | |
| SCHEMBL12184928 | 0.71 | PLK1 (0.53) | KDM4EALDH1A1PLK1L3MBTL1MAPT | |
| SCHEMBL8407148 | 0.69 | KDM4E (0.41) | KDM4EALDH1A1PLK1L3MBTL1MAPT | |
| SCHEMBL30330238 | 0.69 | MAPT (0.41) | KDM4EALDH1A1PLK1MAPTGAA | |
| SCHEMBL25166136 | 0.69 | MAPT (0.41) | KDM4EALDH1A1PLK1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005003124-A1 | HETEROCYCLIC SUBSTITUTED 4-(AMINOMETHYL)-PIPERIDINE BENZAMIDES AS 5HT4-ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-01-13 | — | — | WO | disclosed |