Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | CYP1A1 | P04798 | 4/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.33 |
| ▸ | CYP1B1 | Q16678 | 4/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8302433 | 1.00 | PDE4B (0.41) | PDE4BLMNAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL6837524 | 0.95 | PDE4B (0.39) | PDE4BLMNAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL6837527 | 0.95 | PDE4B (0.39) | PDE4BLMNAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL5723239 | 0.79 | PDE4B (0.38) | PDE4BALDH1A1KDM4EHSD17B10 | |
| SCHEMBL5722978 | 0.79 | PDE4B (0.38) | PDE4BGAANPC1CYP1A1CYP1A2 | |
| SCHEMBL5723244 | 0.79 | PDE4B (0.38) | PDE4BALDH1A1KDM4EHSD17B10 | |
| SCHEMBL5722989 | 0.79 | PDE4B (0.38) | PDE4BGAANPC1CYP1A1CYP1A2 | |
| SCHEMBL5723118 | 0.77 | PDE4B (0.40) | PDE4BALDH1A1CYP1A2PDE4D | |
| SCHEMBL5723107 | 0.77 | PDE4B (0.40) | PDE4BALDH1A1CYP1A2PDE4D | |
| SCHEMBL5723202 | 0.74 | PDE4B (0.36) | PDE4BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0943613-A1 | OXYGENIC HETEROCYCLIC COMPOUNDS | KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) | 1999-09-22 | — | — | EP | disclosed |