Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 6/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13929886 | 0.96 | ACE (0.61) | ACELMNASMN1; SMN2FKBP1A | |
| SCHEMBL8298922 | 0.95 | ACE (0.64) | ACELMNASMN1; SMN2FKBP1A | |
| SCHEMBL8298921 | 0.95 | ACE (0.64) | ACELMNASMN1; SMN2FKBP1A | |
| SCHEMBL8301211 | 0.94 | ACE (0.62) | ACELMNASMN1; SMN2FKBP1ADPP4 | |
| SCHEMBL8298925 | 0.94 | ACE (0.63) | ACELMNASMN1; SMN2FKBP1A | |
| SCHEMBL8298820 | 0.92 | ACE (0.61) | ACELMNASMN1; SMN2FKBP1ADPP4 | |
| SCHEMBL13929850 | 0.91 | ACE (0.62) | ACELMNASMN1; SMN2FKBP1A | |
| SCHEMBL8301131 | 0.91 | ACE (0.62) | ACELMNASMN1; SMN2FKBP1A | |
| SCHEMBL8301015 | 0.90 | ACE (0.61) | ACELMNASMN1; SMN2FKBP1A | |
| SCHEMBL13930016 | 0.88 | ACE (0.58) | ACELMNASMN1; SMN2FKBP1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1635816-B1 | ENALAPRIL-NITROXYDERIVATIVES DERIVATIVES AND RELATED COMPOUNDS AS ACE INHIBITORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | NICOX SA (FR) | 2009-03-04 | — | — | EP | disclosed |
| WO-2004110432-A1 | ENALAPRIL-NITROXYDERIVATIVES DERIVATIVES AND RELATED COMPOUNDS AS ACE INHIBITORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | NICOX S.A. (FR) | 2004-12-23 | — | — | WO | disclosed |