Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | MEN1 | O00255 | 6/20 | 0.60 |
| ▸ | POLB | P06746 | 5/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.60 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.54 |
| ▸ | THRB | P10828 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10725707 | 0.76 | MAPT (1.00) | MAPTKMT2AALDH1A1MEN1POLB | |
| SCHEMBL11418963 | 0.75 | SIRT2 (0.62) | MAPTKMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL11418959 | 0.75 | SIRT2 (0.62) | MAPTKMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL8292171 | 0.75 | MAPT (0.61) | MAPTKMT2AALDH1A1MEN1POLB | |
| SCHEMBL12416873 | 0.74 | MAPT (0.57) | MAPTKMT2AALDH1A1MEN1POLB | |
| SCHEMBL11322819 | 0.70 | CYP3A4 (0.53) | MAPTKMT2AALDH1A1MEN1NPC1 | |
| SCHEMBL11646880 | 0.69 | TDP1 (0.50) | MAPTKMT2AALDH1A1MEN1NPC1 | |
| SCHEMBL11647119 | 0.69 | TDP1 (0.50) | MAPTKMT2AALDH1A1MEN1NPC1 | |
| SCHEMBL10623952 | 0.69 | MAPT (0.70) | MAPTKMT2AALDH1A1MEN1POLB | |
| SCHEMBL17018635 | 0.68 | MAOB (0.56) | MAPTKMT2AALDH1A1MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005037779-A2 | NOVEL DIPEPTIDYL PEPTIDASE IV INHIBITORS USED FOR FUNCTIONALLY INFLUENCING DIFFERENT CELLS AND TREATING IMMUNOLOGICAL, INFLAMMATORY, NEURONAL, AND OTHER DISEASES | IMTM GMBH (DE) | 2005-04-28 | — | — | WO | disclosed |