Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 11/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.60 |
| ▸ | PRKCG | P05129 | 2/20 | 0.60 |
| ▸ | PRKCB | P05771 | 2/20 | 0.60 |
| ▸ | LCK | P06239 | 2/20 | 0.60 |
| ▸ | PRKCA | P17252 | 2/20 | 0.60 |
| ▸ | PRKCH | P24723 | 2/20 | 0.60 |
| ▸ | PRKCI | P41743 | 2/20 | 0.60 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.60 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.60 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.60 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.60 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.60 |
| ▸ | EGFR | P00533 | 1/20 | 0.60 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | IL2 | P60568 | 1/20 | 0.47 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6948987 | 0.95 | ZAP70 (0.66) | ZAP70PRKD3PRKCGPRKCBLCK | |
| SCHEMBL6957167 | 0.81 | ZAP70 (0.82) | ZAP70PRKD3PRKCGPRKCBLCK | |
| SCHEMBL2179548 | 0.76 | DYRK1A (0.49) | ZAP70PRKD3PRKCGPRKCBLCK | |
| SCHEMBL5619205 | 0.75 | ZAP70 (1.00) | ZAP70PRKD3PRKCGPRKCBLCK | |
| SCHEMBL6953476 | 0.74 | ZAP70 (0.72) | ZAP70PRKD3PRKCGPRKCBLCK | |
| SCHEMBL6950873 | 0.73 | ZAP70 (0.79) | ZAP70PRKD3PRKCGPRKCBLCK | |
| SCHEMBL6949520 | 0.72 | ZAP70 (1.00) | ZAP70PRKD3PRKCGPRKCBLCK | |
| SCHEMBL5089234 | 0.72 | DYRK1A (0.64) | DYRK1ACLK4HDAC1 | |
| SCHEMBL7081451 | 0.72 | ZAP70 (0.74) | ZAP70PRKD3PRKCGPRKCBLCK | |
| SCHEMBL6957436 | 0.72 | ZAP70 (0.66) | ZAP70PRKD3PRKCGPRKCBLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934304-A1 | 2-PYRIMIDINEAMINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998018782-A1 | 2-PYRIMIDINEAMINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-05-07 | — | — | WO | disclosed |