SCHEMBL8303920

SCHEMBL8303920

Cn1nc(-c2c(F)cccc2Cl)nc1-c1ccc(Oc2ncc(C(F)(F)F)cc2Cl)c(Cl)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 3/20 0.47
KMT2A Q03164 3/20 0.47
CYP1A2 P05177 1/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2C19 P33261 1/20 0.44
RAB9A P51151 1/20 0.41
LMNA P02545 5/20 0.41
ALDH1A1 P00352 4/20 0.41
POLB P06746 3/20 0.41
NPSR1 Q6W5P4 3/20 0.41
KDM4E B2RXH2 1/20 0.41
SCN9A Q15858 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.38
MAPT P10636 4/20 0.38
HTT P42858 3/20 0.38
MEN1 O00255 2/20 0.38
NPY1R P25929 1/20 0.38
NPY2R P49146 1/20 0.38
SMN1; SMN2 Q16637 3/20 0.37
GAA P10253 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8304863 0.96 HPGD (0.48) HPGDKMT2ACYP1A2CYP3A4CYP2C19
SCHEMBL8303629 0.93 HPGD (0.46) HPGDKMT2ACYP1A2CYP3A4CYP2C19
SCHEMBL8303815 0.90 KMT2A (0.48) HPGDKMT2ACYP1A2CYP3A4CYP2C19
SCHEMBL8942557 0.90 KMT2A (0.48) HPGDKMT2ARAB9ALMNAALDH1A1
SCHEMBL8303158 0.89 KMT2A (0.48) HPGDKMT2ALMNAPOLBNPSR1
SCHEMBL8299345 0.88 NPSR1 (0.37) KMT2ACYP1A2CYP2C19LMNAALDH1A1
SCHEMBL8304100 0.87 MRGPRX4 (0.42) HPGDKMT2ACYP1A2CYP3A4CYP2C19
SCHEMBL8303732 0.87 KMT2A (0.46) HPGDKMT2ACYP1A2CYP3A4CYP2C19
SCHEMBL8942727 0.85 MRGPRX4 (0.47) HPGDKMT2ACYP1A2CYP3A4CYP2C19
SCHEMBL8298899 0.85 KMT2A (0.47) HPGDKMT2ALMNAPOLBSCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0648752-B1 TRIAZOLE DERIVATIVE, INSECTICIDAL/ACARICIDAL AGENT, AND PROCESS FOR PRODUCING THE SAME KUMIAI CHEMICAL INDUSTRY CO (JP) 1999-10-06 EP disclosed
US-5700824-A Triazole derivatives, insecticide, acaricide and methods thereof KUMIAI CHEMICAL INDUSTRIAL CO. LTD. (JP) 1997-12-23 US disclosed
US-5616594-A Triazole derivatives, insecticide, acaricide and methods thereof IHARA CHEMICAL INDUSTRY CO. LTD. (JP) 1997-04-01 US disclosed
EP-0648752-A1 TRIAZOLE DERIVATIVE, INSECTICIDAL/ACARICIDAL AGENT, AND PROCESS FOR PRODUCING THE SAME KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1995-04-19 EP disclosed