Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.65 |
| ▸ | KDR | P35968 | 8/20 | 0.65 |
| ▸ | FBP1 | P09467 | 2/20 | 0.65 |
| ▸ | CLK1 | P49759 | 2/20 | 0.65 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.65 |
| ▸ | AURKA | O14965 | 1/20 | 0.65 |
| ▸ | INSR | P06213 | 1/20 | 0.65 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.65 |
| ▸ | FLT4 | P35916 | 1/20 | 0.65 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.65 |
| ▸ | TEK | Q02763 | 1/20 | 0.65 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.65 |
| ▸ | RET | P07949 | 2/20 | 0.64 |
| ▸ | LCK | P06239 | 3/20 | 0.63 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.62 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.62 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.62 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.62 |
| ▸ | KIF5B | P33176 | 1/20 | 0.62 |
| ▸ | FLT1 | P17948 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8309660 | 0.99 | EGFR (0.65) | EGFRKDRFBP1CLK1ERBB2 | |
| SCHEMBL18158509 | 0.86 | EGFR (0.79) | EGFRKDRCLK1AURKAAURKB | |
| Hydrochloric Acid SCHEMBL8808032 | 0.85 | EGFR (0.79) | EGFRKDRCLK1AURKAAURKB | |
| SCHEMBL8125561 | 0.83 | EGFR (0.61) | EGFRKDRFBP1CLK1ERBB2 | |
| SCHEMBL22590721 | 0.82 | EGFR (0.80) | EGFRKDRFBP1CLK1ERBB2 | |
| SCHEMBL2100447 | 0.82 | KDR (0.80) | EGFRKDRFBP1CLK1ERBB2 | |
| SCHEMBL8309667 | 0.81 | IGF1R (0.67) | EGFRKDRFBP1CLK1ERBB2 | |
| SCHEMBL18158259 | 0.81 | EGFR (0.76) | EGFRKDRFBP1CLK1ERBB2 | |
| SCHEMBL8810743 | 0.81 | KDR (0.58) | EGFRKDRFBP1CLK1ERBB2 | |
| Hydrochloric Acid SCHEMBL8304910 | 0.81 | IGF1R (0.66) | EGFRKDRFBP1CLK1ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | claimed |
| EP-0790986-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | claimed |
| WO-1996015118-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | claimed |
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |
| US-5821246-A | USEFUL AS TYROSINE KINASE INHIBITORS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | ZENECA LIMITED (GB) | 1998-10-13 | — | — | US | disclosed |
| EP-0790986-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996015118-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | disclosed |