Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL900941 | 0.87 | HPGD (0.69) | HPGDNPC1RAB9ACA12CA9 | |
| Hydrochloric Acid SCHEMBL6503199 | 0.85 | HPGD (0.67) | HPGDNPC1RAB9ACA12CA9 | |
| SCHEMBL27598559 | 0.85 | HPGD (0.58) | HPGDNPC1RAB9ACA12CA9 | |
| Hydrochloric Acid SCHEMBL7452576 | 0.85 | HPGD (0.67) | HPGDNPC1RAB9ACA12CA9 | |
| SCHEMBL1337896 | 0.84 | HPGD (0.56) | HPGDNPC1RAB9ACA12CA9 | |
| SCHEMBL13995143 | 0.84 | HPGD (0.60) | HPGDNPC1RAB9ACA12CA9 | |
| SCHEMBL10401033 | 0.83 | HPGD (0.73) | HPGDNPC1RAB9ACA12CA9 | |
| SCHEMBL1007948 | 0.83 | HPGD (0.68) | HPGDNPC1RAB9ACA12CA9 | |
| SCHEMBL3220549 | 0.83 | HPGD (0.68) | HPGDNPC1RAB9ACA12CA9 | |
| SCHEMBL1007950 | 0.83 | HPGD (0.68) | HPGDNPC1RAB9ACA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0833633-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1999-03-24 | — | — | EP | claimed |
| EP-0833633-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-04-08 | — | — | EP | claimed |
| EP-0833633-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1999-03-24 | — | — | EP | disclosed |
| EP-0833633-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-04-08 | — | — | EP | disclosed |