Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 14/20 | 0.71 |
| ▸ | HDAC8 | Q9BY41 | 14/20 | 0.71 |
| ▸ | HDAC6 | Q9UBN7 | 14/20 | 0.71 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | PDE6D | O43924 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.52 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.52 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8305149 | 0.89 | HDAC1 (0.85) | HDAC1HDAC8HDAC6MAPTLMNA | |
| SCHEMBL5565831 | 0.83 | HDAC1 (1.00) | HDAC1HDAC8HDAC6 | |
| SCHEMBL5565827 | 0.83 | HDAC1 (1.00) | HDAC1HDAC8HDAC6 | |
| SCHEMBL8252807 | 0.82 | HDAC1 (0.83) | HDAC1HDAC8HDAC6MAPTTP53 | |
| SCHEMBL5565667 | 0.81 | HDAC1 (0.86) | HDAC1HDAC8HDAC6 | |
| SCHEMBL5565663 | 0.81 | HDAC1 (0.86) | HDAC1HDAC8HDAC6 | |
| SCHEMBL5559945 | 0.80 | HDAC1 (0.87) | HDAC1HDAC8HDAC6 | |
| SCHEMBL5559950 | 0.80 | HDAC1 (0.87) | HDAC1HDAC8HDAC6 | |
| SCHEMBL8242991 | 0.80 | HDAC1 (0.72) | HDAC1HDAC8HDAC6 | |
| SCHEMBL8249421 | 0.80 | HDAC1 (0.73) | HDAC1HDAC8HDAC6MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004082638-A2 | HISTONE DEACETYLASE INHIBITORS | SYRRX, INC. (US) | 2004-09-30 | — | — | WO | disclosed |