Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 9/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.31 |
| ▸ | CETP | P11597 | 1/20 | 0.31 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6903438 | 0.86 | SCN9A (0.38) | SCN9ACETP | |
| SCHEMBL14408388 | 0.84 | SLC5A1 (0.36) | SCN9ASLC5A1 | |
| SCHEMBL5382364 | 0.82 | GRM5 (0.39) | GRM5SMN1; SMN2LMNAHTTSCN9A | |
| SCHEMBL14408392 | 0.80 | SLC16A3 (0.36) | SCN9ASLC5A1CETP | |
| SCHEMBL14727724 | 0.79 | SCN9A (0.39) | SCN9AMAPT | |
| SCHEMBL1659951 | 0.79 | SCN9A (0.33) | SCN9ACETPMAPT | |
| SCHEMBL14717156 | 0.79 | SCN9A (0.37) | SCN9A | |
| SCHEMBL5393515 | 0.79 | SLC16A3 (0.37) | SCN9ASLC5A1CETP | |
| SCHEMBL8306100 | 0.78 | SLC5A1 (0.33) | SCN9ASLC5A1CETP | |
| SCHEMBL14717024 | 0.76 | SCN9A (0.36) | SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7271191-B2 | Pyrazole derivatives as gamma-secretase inhibitors useful in the treatment of Alzheimer's disease | MERCK SHARP & DOHME LTD. (GB) | 2007-09-18 | — | — | US | disclosed |
| US-7271191-B2 | Pyrazole derivatives as gamma-secretase inhibitors useful in the treatment of Alzheimer's disease | MERCK SHARP & DOHME LTD. (GB) | 2007-09-18 | — | — | US | disclosed |
| WO-2004089911-A1 | PYRAZOLE DERIVATIVES AS GAMMA-SECRETASE INHIBITORS USEFUL IN THE TREATMENT OF ALZHEIMER’S DISEASE | MERCK SHARP & DOHME LIMITED (GB) | 2004-10-21 | — | — | WO | disclosed |