Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 5/20 | 0.44 |
| ▸ | STS | P08842 | 2/20 | 0.44 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL653312 | 1.00 | KMT2A (0.47) | KMT2AMEN1ALKALDH1A1LMNA | |
| SCHEMBL6095235 | 1.00 | KMT2A (0.47) | KMT2AMEN1ALKALDH1A1LMNA | |
| SCHEMBL6095239 | 1.00 | KMT2A (0.47) | KMT2AMEN1ALKALDH1A1LMNA | |
| SCHEMBL16422384 | 0.88 | ALK (0.48) | KMT2AMEN1ALK | |
| SCHEMBL4919416 | 0.88 | ALK (0.48) | KMT2AMEN1ALK | |
| SCHEMBL4926305 | 0.88 | ALK (0.48) | KMT2AMEN1ALK | |
| SCHEMBL654443 | 0.88 | KMT2A (0.47) | KMT2AMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL2239220 | 0.88 | ALK (0.49) | KMT2AALKALDH1A1MAPTKDM1A | |
| SCHEMBL20820421 | 0.88 | ALK (0.49) | KMT2AALKALDH1A1MAPTKDM1A | |
| SCHEMBL2244783 | 0.88 | ALK (0.49) | KMT2AALKALDH1A1MAPTKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004080460-A1 | SUBSTITUTED PIPERIDINES AS NOVEL MDM2-p53 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-09-23 | — | — | WO | disclosed |