Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.80 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | BACE1 | P56817 | 4/20 | 0.63 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8305999 | 0.89 | MEN1 (1.00) | MEN1KMT2AMAPTPOLBBACE1 | |
| SCHEMBL8308896 | 0.88 | BACE1 (0.68) | MEN1KMT2AMAPTBACE1TP53 | |
| SCHEMBL8311540 | 0.87 | KMT2A (0.91) | MEN1KMT2AMAPTPOLBBACE1 | |
| SCHEMBL8306328 | 0.87 | BACE1 (0.67) | MEN1KMT2AMAPTBACE1TP53 | |
| SCHEMBL8311546 | 0.86 | MEN1 (0.83) | MEN1KMT2AMAPTPOLBBACE1 | |
| SCHEMBL8305849 | 0.86 | MEN1 (0.82) | MEN1KMT2AMAPTPOLBBACE1 | |
| SCHEMBL19126011 | 0.85 | MEN1 (0.62) | MEN1KMT2AMAPTPOLBBACE1 | |
| SCHEMBL8305766 | 0.85 | KMT2A (0.89) | MEN1KMT2AMAPTPOLBBACE1 | |
| SCHEMBL8306379 | 0.84 | KMT2A (0.80) | MEN1KMT2AMAPTPOLBBACE1 | |
| SCHEMBL8305903 | 0.84 | MEN1 (0.91) | MEN1KMT2AMAPTPOLBBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004078731-A1 | QUINOLINE-CARBOXYLIC ACIDS AND THE DERIVATIVES THEREOF, A FOCUSED LIBRARY | 'CHEMICAL DIVERSITY RESEARCH INSTITUTE', LTD. (RU) | 2004-09-16 | — | — | WO | disclosed |