Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8305878 | 0.81 | GRM5 (0.68) | GRM5ASIC3 | |
| SCHEMBL5582696 | 0.81 | GRM5 (1.00) | GRM5ASIC3 | |
| SCHEMBL5582790 | 0.80 | GRM5 (1.00) | GRM5ASIC3 | |
| SCHEMBL5583065 | 0.78 | GRM5 (0.76) | GRM5ASIC3 | |
| SCHEMBL5582599 | 0.75 | GRM5 (0.71) | GRM5ASIC3 | |
| SCHEMBL5582868 | 0.73 | GRM5 (1.00) | GRM5ASIC3 | |
| SCHEMBL5582841 | 0.73 | GRM5 (1.00) | GRM5ASIC3 | |
| SCHEMBL5582683 | 0.73 | GRM5 (0.83) | GRM5ASIC3 | |
| SCHEMBL5582774 | 0.72 | GRM5 (1.00) | GRM5ASIC3 | |
| SCHEMBL5582792 | 0.72 | GRM5 (1.00) | GRM5ASIC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070027321-A1 | Bipyridyl amines and ethers as modulators of metabotropic glutamate receptor-5 | MERCK SHARP & DOHME CORP. | 2007-02-01 | — | — | US | disclosed |
| US-20070027321-A1 | Bipyridyl amines and ethers as modulators of metabotropic glutamate receptor-5 | MERCK SHARP & DOHME CORP. | 2007-02-01 | — | — | US | disclosed |
| WO-2005021529-A1 | BIPYRIDYL AMINES AND ETHERS AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | MERCK & CO., INC. (US) | 2005-03-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027321-A1 | Bipyridyl amines and ethers as modulators of metabotropic glutamate receptor-5 | GRM5, GRIK5, GRM1 | GRM5 1/4885ASIC3 366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.