Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.53 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.49 |
| ▸ | HRH1 | P35367 | 2/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6905786 | 0.91 | KCNH2 (0.56) | KCNH2SLC6A2HRH1HRH3CHRM2 | |
| SCHEMBL3169926 | 0.85 | TAAR1 (0.45) | MEN1KMT2AUSP2ALDH1A1LMNA | |
| SCHEMBL9249000 | 0.82 | SLC6A2 (0.64) | MEN1KMT2AKCNH2SLC6A2HRH1 | |
| SCHEMBL9021231 | 0.82 | KCNH2 (0.49) | KCNH2SLC6A2HRH1HRH3CHRM2 | |
| SCHEMBL9154096 | 0.82 | KCNH2 (0.49) | KCNH2SLC6A2HRH1HRH3CHRM2 | |
| SCHEMBL9021167 | 0.82 | KCNH2 (0.49) | KCNH2SLC6A2HRH1HRH3CHRM2 | |
| SCHEMBL9021237 | 0.82 | KCNH2 (0.49) | KCNH2SLC6A2HRH1HRH3CHRM2 | |
| SCHEMBL9021947 | 0.82 | KCNH2 (0.49) | KCNH2SLC6A2HRH1HRH3CHRM2 | |
| SCHEMBL9021235 | 0.82 | KCNH2 (0.49) | KCNH2SLC6A2HRH1HRH3CHRM2 | |
| SCHEMBL9154394 | 0.82 | KCNH2 (0.49) | KCNH2SLC6A2HRH1HRH3CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915843-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSES | SMITHKLINE BEECHAM PLC (GB) | 1999-05-19 | — | — | EP | disclosed |
| WO-1997041098-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-11-06 | — | — | WO | disclosed |