Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.82 |
| ▸ | EGFR | P00533 | 10/20 | 0.74 |
| ▸ | KDR | P35968 | 5/20 | 0.74 |
| ▸ | RET | P07949 | 3/20 | 0.74 |
| ▸ | LCK | P06239 | 3/20 | 0.72 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.69 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.69 |
| ▸ | SRC | P12931 | 1/20 | 0.67 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.65 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.65 |
| ▸ | AURKA | O14965 | 1/20 | 0.62 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.62 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.61 |
| ▸ | FLT1 | P17948 | 1/20 | 0.61 |
| ▸ | GAK | O14976 | 1/20 | 0.61 |
| ▸ | STK10 | O94804 | 1/20 | 0.61 |
| ▸ | FLT3 | P36888 | 1/20 | 0.61 |
| ▸ | JAK3 | P52333 | 1/20 | 0.61 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.61 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8308528 | 0.99 | LRRK2 (0.81) | LRRK2EGFRKDRRETLCK | |
| SCHEMBL14982743 | 0.97 | LRRK2 (0.84) | LRRK2EGFRKDRRETLCK | |
| SCHEMBL12069855 | 0.95 | LRRK2 (0.74) | LRRK2EGFRKDRRETLCK | |
| SCHEMBL14982746 | 0.91 | LRRK2 (0.69) | LRRK2EGFRKDRRETLCK | |
| SCHEMBL14982748 | 0.90 | LRRK2 (0.67) | LRRK2EGFRKDRRETLCK | |
| SCHEMBL2392081 | 0.88 | LRRK2 (0.68) | LRRK2EGFRKDRRETLCK | |
| SCHEMBL8807167 | 0.88 | EGFR (0.75) | LRRK2EGFRKDRRETLCK | |
| SCHEMBL12306949 | 0.87 | LRRK2 (0.67) | LRRK2EGFRKDRRETLCK | |
| SCHEMBL1387182 | 0.86 | EGFR (0.94) | EGFRKDRRETLCKSRC | |
| SCHEMBL1257431 | 0.86 | EGFR (1.00) | EGFRKDRRETLCKERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | claimed |
| EP-0790986-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | claimed |
| WO-1996015118-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | claimed |
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |
| US-5821246-A | USEFUL AS TYROSINE KINASE INHIBITORS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | ZENECA LIMITED (GB) | 1998-10-13 | — | — | US | disclosed |
| EP-0790986-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996015118-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | disclosed |