Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.72 |
| ▸ | ERBB2 | P04626 | 10/20 | 0.72 |
| ▸ | LCK | P06239 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.47 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8309603 | 0.90 | EGFR (0.71) | EGFRERBB2LCKERBB4ERBB3 | |
| SCHEMBL8307102 | 0.85 | EGFR (0.76) | EGFRERBB2LCKERBB4ABCG2 | |
| SCHEMBL4560407 | 0.85 | EGFR (0.76) | EGFRERBB2LCKCYP1A2CYP3A4 | |
| SCHEMBL8309272 | 0.85 | EGFR (0.76) | EGFRERBB2LCKLMNAERBB4 | |
| Hydrochloric Acid SCHEMBL6185804 | 0.84 | EGFR (0.75) | EGFRERBB2LCKCYP1A2CYP3A4 | |
| SCHEMBL8306859 | 0.84 | EGFR (1.00) | EGFRERBB2LCKERBB4ABCG2 | |
| SCHEMBL8309699 | 0.83 | ERBB2 (0.68) | EGFRERBB2LCKERBB4ERBB3 | |
| Hydrochloric Acid SCHEMBL8309362 | 0.83 | EGFR (0.98) | EGFRERBB2LCKERBB4ABCG2 | |
| SCHEMBL8308380 | 0.83 | EGFR (0.82) | EGFRERBB2LCKERBB4ABCG2 | |
| SCHEMBL8309178 | 0.82 | EGFR (0.70) | EGFRERBB2LCKERBB4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |
| US-5821246-A | USEFUL AS TYROSINE KINASE INHIBITORS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | ZENECA LIMITED (GB) | 1998-10-13 | — | — | US | disclosed |
| EP-0790986-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996015118-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | disclosed |