Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 9/20 | 0.73 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.56 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.55 |
| ▸ | PIM1 | P11309 | 2/20 | 0.55 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.55 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.55 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.52 |
| ▸ | DAPK2 | Q9UIK4 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10116343 | 0.89 | PDE9A (0.69) | PDE9APDE1CMAPTLMNATP53 | |
| SCHEMBL12436897 | 0.89 | PDE9A (0.63) | PDE9APDE1CDAPK3PIM1PIM3 | |
| SCHEMBL12824707 | 0.89 | PDE9A (0.63) | PDE9APDE1CMAPTLMNAALDH1A1 | |
| SCHEMBL1456832 | 0.89 | PDE9A (0.63) | PDE9APDE1CDAPK3PIM1PIM3 | |
| SCHEMBL8307144 | 0.88 | PDE9A (0.73) | PDE9APDE1CDAPK3PIM1PIM3 | |
| SCHEMBL12250672 | 0.87 | PDE9A (0.61) | PDE9APDE1CDAPK3PIM1PIM3 | |
| SCHEMBL8306354 | 0.87 | PDE9A (0.64) | PDE9APDE1CMAPTLMNAALDH1A1 | |
| SCHEMBL8311055 | 0.86 | PDE9A (0.60) | PDE9APDE1CMAPTLMNAALDH1A1 | |
| SCHEMBL1456761 | 0.86 | PDE9A (0.71) | PDE9APDE1CMAPTLMNAALDH1A1 | |
| SCHEMBL10116371 | 0.85 | PDE9A (0.69) | PDE9APDE1CMAPTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8822479-B2 | 6-cyclylmethyl-and 6-alkylmethyl-substituted pyrazolepyrimidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-09-02 | — | — | US | disclosed |
| US-8822479-B2 | 6-cyclylmethyl-and 6-alkylmethyl-substituted pyrazolepyrimidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-09-02 | — | — | US | disclosed |
| US-8642605-B2 | 6-cyclylmethyl-and 6-alkylmethyl-substituted pyrazolepyrimidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-02-04 | — | — | US | disclosed |
| US-8642605-B2 | 6-cyclylmethyl-and 6-alkylmethyl-substituted pyrazolepyrimidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-02-04 | — | — | US | disclosed |
| EP-2298773-B1 | 6-Cyclomethyl and 6-alkylmethyl substituted pyrazolopyrimidines | BOEHRINGER INGELHEIM INT (DE) | 2013-06-19 | — | — | EP | disclosed |
| US-20120010224-A1 | 6-CYCLYLMETHYL-AND 6-ALKYLMETHYL-SUBSTITUTED PYRAZOLEPYRIMIDINES | HENDRIX MARTIN (DE) | 2012-01-12 | — | — | US | disclosed |
| US-20120010224-A1 | 6-CYCLYLMETHYL-AND 6-ALKYLMETHYL-SUBSTITUTED PYRAZOLEPYRIMIDINES | HENDRIX MARTIN (DE) | 2012-01-12 | — | — | US | disclosed |
| US-8044060-B2 | 6-cyclylmethyl- and 6-alkylmethyl pyrazolo[3,4-D]pyrimidines, methods for their preparation and methods for their use to treat impairments of perception, concentration learning and/or memory | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-10-25 | — | — | US | disclosed |
| US-8044060-B2 | 6-cyclylmethyl- and 6-alkylmethyl pyrazolo[3,4-D]pyrimidines, methods for their preparation and methods for their use to treat impairments of perception, concentration learning and/or memory | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-10-25 | — | — | US | disclosed |
| EP-2298773-A1 | 6-Cyclomethyl and 6-alkylmethyl substituted pyrazolopyrimidines | Boehringer Ingelheim International GmbH (DE) | 2011-03-23 | — | — | EP | disclosed |
| US-20110065730-A1 | 6-CYCLYLMETHYL-AND 6-ALKYLMETHYL-SUBSTITUTED PYRAZOLEPYRIMIDINES | HENDRIX MARTIN | 2011-03-17 | — | — | US | disclosed |
| US-20110065730-A1 | 6-CYCLYLMETHYL-AND 6-ALKYLMETHYL-SUBSTITUTED PYRAZOLEPYRIMIDINES | HENDRIX MARTIN | 2011-03-17 | — | — | US | disclosed |
| US-20070105876-A1 | 6-Cyclylmethyl- and 6-alkylmethyl-substituted pyrazolepyrimidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-05-10 | — | — | US | disclosed |
| US-20070105876-A1 | 6-Cyclylmethyl- and 6-alkylmethyl-substituted pyrazolepyrimidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-05-10 | — | — | US | disclosed |
| WO-2004099211-A1 | 6-CYCLYLMETHYL- AND 6-ALKYLMETHYL-SUBSTITUTED PYRAZOLOPYRIMIDINES | BAYER HEALTHCARE AG (DE) | 2004-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110065730-A1 | 6-CYCLYLMETHYL-AND 6-ALKYLMETHYL-SUBSTITUTED PYRAZOLEPYRIMIDINES | GRM6, P2RX6, P2RY6 | PDE9A 384/4885PDE1C 464/4885DAPK3 1009/4885 |
| US-20070105876-A1 | 6-Cyclylmethyl- and 6-alkylmethyl-substituted pyrazolepyrimidines | GRM6, P2RX6, P2RY6 | PDE9A 384/4885PDE1C 464/4885DAPK3 1009/4885 |
| US-20120010224-A1 | 6-CYCLYLMETHYL-AND 6-ALKYLMETHYL-SUBSTITUTED PYRAZOLEPYRIMIDINES | GRM6, P2RX6, P2RY6 | PDE9A 384/4885PDE1C 464/4885DAPK3 1009/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.