Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MC4R | P32245 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | MC3R | P41968 | 1/20 | 0.30 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
| ▸ | PLAU | P00749 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25660370 | 0.82 | HCAR2 (0.44) | HCAR2 | |
| SCHEMBL1484347 | 0.76 | EPHX1 (0.44) | HCAR2CYP19A1LRRK2AR | |
| SCHEMBL1354541 | 0.75 | F7 (0.50) | HCAR2 | |
| SCHEMBL1354543 | 0.75 | F7 (0.50) | HCAR2 | |
| SCHEMBL2178492 | 0.73 | NAPRT (0.39) | ADORA3 | |
| SCHEMBL2178495 | 0.73 | NAPRT (0.39) | ADORA3 | |
| SCHEMBL5399972 | 0.72 | CYP2C9 (0.37) | CYP11B2TSHR | |
| SCHEMBL2438138 | 0.71 | AKR1C3 (0.42) | HCAR2AR | |
| SCHEMBL28090653 | 0.69 | — | — | |
| SCHEMBL15797528 | 0.69 | AKR1C3 (0.35) | HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0630244-B1 | MUSCARINIC AGONISTS | UNIV TOLEDO (US) | 1999-12-01 | — | — | EP | disclosed |
| US-5403845-A | Cognition activators; Alzheimer*s disaease | UNIVERSITY OF TOLEDO (US) | 1995-04-04 | — | — | US | disclosed |
| EP-0630244-A1 | MUSCARINIC AGONISTS | THE UNIVERSITY OF TOLEDO (US) | 1994-12-28 | — | — | EP | disclosed |
| EP-0630244-A4 | MUSCARINIC AGONISTS. | UNIV TOLEDO (US) | 1994-04-07 | — | — | EP | disclosed |
| WO-1993003726-A1 | MUSCARINIC AGONISTS | THE UNIVERSITY OF TOLEDO (US) | 1993-03-04 | — | — | WO | disclosed |
| US-5175166-A | Cognition activators | THE UNIVERSITY OF TOLEDO (US) | 1992-12-29 | — | — | US | disclosed |