Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | ANPEP | P15144 | 1/20 | 0.46 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845511 | 0.89 | HSD17B10 (0.57) | HSD17B10CYP3A4CYP2D6ANPEPERAP2 | |
| SCHEMBL8311065 | 0.88 | RAD52 (0.47) | HSD17B10CYP3A4CYP2D6ANPEPERAP2 | |
| SCHEMBL8306592 | 0.88 | CXCR4 (0.46) | HSD17B10CYP3A4CYP2D6ANPEPERAP2 | |
| SCHEMBL29860764 | 0.87 | HSD17B10 (0.55) | HSD17B10CYP3A4CYP2D6ANPEPERAP2 | |
| SCHEMBL6051874 | 0.83 | ACE2 (0.52) | HSD17B10CYP3A4CYP2D6ANPEPERAP2 | |
| SCHEMBL8308208 | 0.80 | CARM1 (0.50) | ACE2KMT2ASIGMAR1CA1CA2 | |
| SCHEMBL302850 | 0.79 | ACE2 (0.72) | HSD17B10CYP3A4CYP2D6ANPEPERAP2 | |
| SCHEMBL18024089 | 0.79 | HSD17B10 (0.48) | HSD17B10CYP3A4CYP2D6ANPEPERAP2 | |
| SCHEMBL22416418 | 0.79 | HSD17B10 (0.48) | HSD17B10CYP3A4CYP2D6ANPEPERAP2 | |
| SCHEMBL3522881 | 0.79 | ANPEP (0.50) | HSD17B10CYP3A4CYP2D6ANPEPERAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |