Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 6/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 5/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.91 |
| ▸ | IGF1R | P08069 | 1/20 | 0.80 |
| ▸ | PIM1 | P11309 | 2/20 | 0.75 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.75 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.75 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.75 |
| ▸ | CISD1 | Q9NZ45 | 3/20 | 0.74 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.73 |
| ▸ | MGAM | O43451 | 2/20 | 0.69 |
| ▸ | GAA | P10253 | 2/20 | 0.69 |
| ▸ | SI | P14410 | 2/20 | 0.69 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8307072 | 1.00 | PDE4B (1.00) | PDE4BPDE3AMEN1KMT2AALDH1A1 | |
| SCHEMBL8308535 | 0.95 | PDE4B (1.00) | PDE4BPDE3AMEN1KMT2AALDH1A1 | |
| SCHEMBL8308532 | 0.95 | PDE4B (1.00) | PDE4BPDE3AMEN1KMT2AALDH1A1 | |
| SCHEMBL8311580 | 0.94 | PDE4B (1.00) | PDE4BPDE3AMEN1KMT2AALDH1A1 | |
| SCHEMBL8311581 | 0.94 | PDE4B (1.00) | PDE4BPDE3AMEN1KMT2AALDH1A1 | |
| SCHEMBL8171885 | 0.90 | PDE4B (1.00) | PDE4BPDE3AMEN1KMT2AALDH1A1 | |
| SCHEMBL15421279 | 0.90 | PDE4B (1.00) | PDE4BPDE3AMEN1KMT2AALDH1A1 | |
| SCHEMBL8171882 | 0.90 | PDE4B (1.00) | PDE4BPDE3AMEN1KMT2AALDH1A1 | |
| SCHEMBL8310547 | 0.90 | PDE4B (0.81) | PDE4BPDE3AMEN1KMT2AALDH1A1 | |
| SCHEMBL8310546 | 0.90 | PDE4B (0.81) | PDE4BPDE3AMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915090-A1 | Compounds useful as hypoglycemic agents and for treating Alzheimer's disease | ELI LILLY AND COMPANY (US) | 1999-05-12 | — | — | EP | disclosed |
| US-5716975-A | NONTOXIC RHODANINE DERIVATIVES; ANTIDIABETIC AGENTS, CATHEPSIN D INHIBITORS, B-AMYLOID PROTEIN REDUCTION | ELI LILLY AND COMPANY (US) | 1998-02-10 | — | — | US | disclosed |
| US-5661168-A | ADMINISTERING RHODANINE DERIVATIVES TO CONTROL DIABETES | ELI LILLY AND COMPANY (US) | 1997-08-26 | — | — | US | disclosed |
| US-5523314-A | RHODANINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1996-06-04 | — | — | US | disclosed |
| EP-0587377-A2 | Thiazolidinone derivatives as hypoglycemic agents and for treating Alzheimer's disease | ELI LILLY AND COMPANY (US) | 1994-03-16 | — | — | EP | disclosed |