Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.47 |
| ▸ | RAB9A | P51151 | 8/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8307744 | 1.00 | NPC1 (0.47) | NPC1RAB9AL3MBTL1PKMATM | |
| SCHEMBL25263264 | 0.83 | NPC1 (0.46) | NPC1RAB9AL3MBTL1PKMATM | |
| SCHEMBL10566200 | 0.77 | NPC1 (0.47) | NPC1RAB9AL3MBTL1PKMATM | |
| SCHEMBL8304851 | 0.77 | KDR (0.39) | POLB | |
| SCHEMBL10566209 | 0.77 | NPC1 (0.47) | NPC1RAB9AL3MBTL1PKMATM | |
| SCHEMBL8304853 | 0.77 | KDR (0.39) | POLB | |
| SCHEMBL18433248 | 0.75 | NPC1 (0.54) | NPC1RAB9AL3MBTL1PKMATM | |
| SCHEMBL8308311 | 0.75 | SMN1; SMN2 (0.40) | NPC1RAB9AL3MBTL1PKMATM | |
| SCHEMBL8308309 | 0.75 | SMN1; SMN2 (0.40) | NPC1RAB9AL3MBTL1PKMATM | |
| SCHEMBL11483820 | 0.74 | NPC1 (0.52) | NPC1RAB9AL3MBTL1PKMATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0581250-B1 | Process for biotechnical preparation of L-thienylalanines in enantiomere pure form from 2-hydroxy-3-thienyl-acrylic acids and their use | HOECHST AG (DE) | 1999-03-03 | — | — | EP | disclosed |
| US-5780640-A | Process for the biotechnological preparation of L-thienylalanines in enantiomerically pure form from 2-hydroxy-3-thienylacrylic acids and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-07-14 | — | — | US | disclosed |
| US-5688672-A | Process for the biotechnological preparation of L-thienylalanines in enantiomerically pure form from 2-hydroxy-3-thienylacrylic acids | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-11-18 | — | — | US | disclosed |
| US-5480786-A | Process for the biotechnological preparation of l-thienylalanines in enantiomerically pure form from 2-hydroxy-3-thienylacrylic acids, and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-01-02 | — | — | US | disclosed |
| EP-0581250-A2 | Process for biotechnical preparation of L-thienylalanines in enantiomere pure form from 2-hydroxy-3-thienyl-acrylic acids and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-02-02 | — | — | EP | disclosed |