Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.52 |
| ▸ | TCF4 | P15884 | 1/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.51 |
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8307610 | 0.88 | MAPT (0.80) | MAPTMAPK1KMT2AALDH1A1LMNA | |
| SCHEMBL8310527 | 0.86 | MAPT (0.59) | MAPTMAPK1KMT2AALDH1A1LMNA | |
| SCHEMBL8713783 | 0.84 | PDE4B (0.63) | MAPTMAPK1KMT2AALDH1A1LMNA | |
| SCHEMBL12008421 | 0.82 | CTNNB1 (0.73) | MAPTMAPK1KMT2AALDH1A1AKR1B1 | |
| SCHEMBL12008497 | 0.82 | CTNNB1 (0.73) | MAPTMAPK1KMT2AALDH1A1AKR1B1 | |
| SCHEMBL12008513 | 0.81 | CTNNB1 (0.81) | MAPTMAPK1KMT2AAKR1B1MEN1 | |
| SCHEMBL12008416 | 0.81 | CTNNB1 (0.75) | MAPTMAPK1KMT2AALDH1A1AKR1B1 | |
| SCHEMBL5123134 | 0.81 | CTNNB1 (0.77) | MAPTMAPK1KMT2AAKR1B1MEN1 | |
| SCHEMBL5123932 | 0.81 | CTNNB1 (0.77) | MAPTMAPK1KMT2AAKR1B1MEN1 | |
| SCHEMBL14277840 | 0.81 | CTNNB1 (0.77) | MAPTMAPK1KMT2AAKR1B1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915090-A1 | Compounds useful as hypoglycemic agents and for treating Alzheimer's disease | ELI LILLY AND COMPANY (US) | 1999-05-12 | — | — | EP | disclosed |
| US-5716975-A | NONTOXIC RHODANINE DERIVATIVES; ANTIDIABETIC AGENTS, CATHEPSIN D INHIBITORS, B-AMYLOID PROTEIN REDUCTION | ELI LILLY AND COMPANY (US) | 1998-02-10 | — | — | US | disclosed |
| US-5523314-A | RHODANINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1996-06-04 | — | — | US | disclosed |
| US-5492955-A | COMPRISING A CURABLE MIXTURE OF AN ACRYLIC BINDER CONTAINING EPOXY GROUPS, A DICARBOXYLIC ACID OR ANHYDRIDE CURING AGENT AND A POLYURETHANE CONTAINING URETIDIONE | BAYER AKTIENGESELLSCHAFT (DE) | 1996-02-20 | — | — | US | disclosed |
| EP-0587377-A2 | Thiazolidinone derivatives as hypoglycemic agents and for treating Alzheimer's disease | ELI LILLY AND COMPANY (US) | 1994-03-16 | — | — | EP | disclosed |