Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 6/20 | 0.43 |
| ▸ | BRD2 | P25440 | 4/20 | 0.42 |
| ▸ | BRD3 | Q15059 | 4/20 | 0.42 |
| ▸ | BRDT | Q58F21 | 4/20 | 0.42 |
| ▸ | MAOB | P27338 | 4/20 | 0.41 |
| ▸ | MAOA | P21397 | 3/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8309780 | 0.97 | BRD4 (0.46) | BRD4BRD2BRD3BRDTMAOB | |
| SCHEMBL4575775 | 0.93 | CYP1B1 (0.46) | MAOBMAOAABCB1POLBMAPT | |
| SCHEMBL4575066 | 0.93 | CYP1B1 (0.46) | MAOBMAOAABCB1POLBMAPT | |
| SCHEMBL4574734 | 0.93 | CYP1B1 (0.46) | MAOBMAOAABCB1POLBMAPT | |
| SCHEMBL8859601 | 0.90 | BRD4 (0.39) | BRD4BRD2BRD3BRDTMAOB | |
| SCHEMBL8859603 | 0.90 | BRD4 (0.39) | BRD4BRD2BRD3BRDTMAOB | |
| SCHEMBL4575202 | 0.89 | CYP1A1 (0.42) | ABCB1KDM4EPOLBMAPTABCG2 | |
| SCHEMBL8306985 | 0.89 | BRD4 (0.47) | BRD4BRD2BRD3BRDTMAOB | |
| SCHEMBL8431088 | 0.85 | HPGD (0.43) | BRD4BRD2BRD3BRDTMAOB | |
| SCHEMBL8431286 | 0.83 | KDM4E (0.40) | BRD4BRD2BRD3BRDTMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709383-B1 | Diosmetin derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1999-12-15 | — | — | EP | disclosed |
| US-5629339-A | CHRONIC VENOUS INSUFFICIENCY | ADIR ET COMPAGNIE (FR) | 1997-05-13 | — | — | US | disclosed |
| EP-0709383-A1 | Diosmetin derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-05-01 | — | — | EP | disclosed |