Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRA | P18433 | 1/20 | 0.53 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.50 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.50 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.50 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.50 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | FDPS | P14324 | 1/20 | 0.45 |
| ▸ | ACACB | O00763 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20188382 | 0.88 | PTPRA (0.55) | PTPRAGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL20188669 | 0.88 | PTPRA (0.55) | PTPRAGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL22457372 | 0.83 | PTPRA (0.48) | PTPRAGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL20190939 | 0.83 | PTPRA (0.48) | PTPRAGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL9321384 | 0.83 | GRIN2D (0.51) | PTPRAGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL20189005 | 0.82 | PTPRA (0.47) | PTPRAGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL22457805 | 0.82 | PTPRA (0.47) | PTPRAGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL29735572 | 0.81 | CYP1A2 (0.46) | PTPRAGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL16703260 | 0.81 | PTPRA (0.43) | PTPRAGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL19603005 | 0.81 | PTPRA (0.43) | PTPRAGRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612314-B1 | 2-PYRAZINYLETHYLAMINE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | ASTRA AB (SE) | 1999-12-29 | — | — | EP | disclosed |
| US-5607935-A | 2-heterocyclicethylamine derivatives and their use as pharmaceuticals | FISONS CORPORATION (US) | 1997-03-04 | — | — | US | disclosed |
| EP-0612314-A1 | 2-HETEROCYCLICETHYLAMINE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | Astra Aktiebolag (SE) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993009095-A1 | 2-HETEROCYCLICETHYLAMINE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | FISONS CORPORATION (US) | 1993-05-13 | — | — | WO | disclosed |
| EP-0540318-A1 | 2-Heterocyclicethylamine derivatives and their use as pharmaceuticals | FISONS CORPORATION (US) | 1993-05-05 | — | — | EP | disclosed |