Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 9/20 | 0.57 |
| ▸ | CHUK | O15111 | 7/20 | 0.57 |
| ▸ | MTOR | P42345 | 2/20 | 0.54 |
| ▸ | SMG1 | Q96Q15 | 2/20 | 0.54 |
| ▸ | CDK1 | P06493 | 3/20 | 0.49 |
| ▸ | CDK2 | P24941 | 3/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | CDK4 | P11802 | 1/20 | 0.49 |
| ▸ | WEE1 | P30291 | 1/20 | 0.49 |
| ▸ | CDK7 | P50613 | 1/20 | 0.49 |
| ▸ | CDK9 | P50750 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 5/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8311634 | 0.90 | IKBKB (0.54) | IKBKBCHUKMTORSMG1CDK1 | |
| SCHEMBL8311025 | 0.89 | HTT (0.58) | IKBKBCHUKMTORSMG1MAPK8 | |
| SCHEMBL8308563 | 0.89 | IKBKB (0.54) | IKBKBCHUKMTORSMG1JAK2 | |
| SCHEMBL8308545 | 0.89 | IKBKB (0.69) | IKBKBCHUKMTORSMG1 | |
| SCHEMBL14063902 | 0.88 | IKBKB (0.54) | IKBKBCHUKMTORSMG1PIK3CA | |
| SCHEMBL14063805 | 0.88 | IKBKB (0.54) | IKBKBCHUKMTORSMG1PIK3CA | |
| SCHEMBL4062111 | 0.88 | IKBKB (0.52) | IKBKBCHUKMTORSMG1JAK2 | |
| SCHEMBL14063881 | 0.88 | IKBKB (0.56) | IKBKBCHUKMTORSMG1CDK1 | |
| SCHEMBL8314809 | 0.88 | MTOR (0.57) | IKBKBCHUKMTORSMG1CDK1 | |
| SCHEMBL8311426 | 0.88 | IKBKB (0.56) | IKBKBCHUKMTORSMG1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| WO-2004084901-A1 | METHODS FOR TREATING OR PREVENTING AN INFLAMMATORY OR METABOLIC CONDITION BY INHIBITING JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-10-07 | — | — | WO | disclosed |