Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 19/20 | 0.66 |
| ▸ | FNTB | P49356 | 19/20 | 0.66 |
| ▸ | PGGT1B | P53609 | 13/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.54 |
| ▸ | NRAS | P01111 | 1/20 | 0.54 |
| ▸ | HRAS | P01112 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8420854 | 0.99 | FNTA (0.65) | FNTAFNTBPGGT1BKCNH2NRAS | |
| SCHEMBL8299809 | 0.85 | FNTA (0.54) | FNTAFNTBPGGT1BKCNH2NRAS | |
| SCHEMBL7838156 | 0.85 | FNTA (0.59) | FNTAFNTBPGGT1BKCNH2 | |
| Hydrochloric Acid SCHEMBL8301587 | 0.85 | FNTA (0.54) | FNTAFNTBPGGT1BKCNH2NRAS | |
| Hydrochloric Acid SCHEMBL7838838 | 0.84 | FNTA (0.58) | FNTAFNTBPGGT1BKCNH2 | |
| SCHEMBL8420978 | 0.83 | FNTA (0.56) | FNTAFNTBPGGT1BKCNH2NRAS | |
| Hydrochloric Acid SCHEMBL8301027 | 0.83 | FNTA (0.55) | FNTAFNTBPGGT1BKCNH2NRAS | |
| SCHEMBL8422489 | 0.82 | FNTA (0.69) | FNTAFNTBPGGT1BKCNH2 | |
| SCHEMBL8422496 | 0.82 | FNTA (0.69) | FNTAFNTBPGGT1BKCNH2 | |
| SCHEMBL7527887 | 0.82 | FNTA (0.71) | FNTAFNTBPGGT1BKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965578-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-10-12 | — | — | US | claimed |
| EP-0897303-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-02-24 | — | — | EP | claimed |
| EP-0897303-A4 | — | — | 1999-02-24 | — | — | EP | claimed |
| WO-1997036605-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | claimed |
| US-5965578-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-10-12 | — | — | US | disclosed |